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Abstract

MOLECULAR DOCKING STUDIES OF IMIDAZOLE DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS

Prajakta S. Pujari*

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Abstract

Recent years have seen a focus on imidazole compounds containing two nitrogen atoms in a five-membered aromatic ring. The human immunodeficiency virus (HIV) targets the immune system. Many people are diagnosed with HIV each year, and up to one in seven HIVpositive individuals are unaware of their condition. A serious worldwide health concern continues to be the human immunodeficiency virus (HIV), particularly HIV-1 infection and the development of acquired immune deficiency syndrome (AIDS). Imidazole structure with two azole groups in the Meta position of a five-membered ring, and belongs to a significant class of heterocycles used in drug discovery. It has promising antiviral efficacy against both drug-sensitive and drug-resistant HIV strains and may exert anti-HIV action through a variety of pathways. With the use of SAR and docking study, this research has advanced regarding the anti-HIV potential of imidazole derivatives with receptor HIV-1RT. According to molecular docking, the compound's inhibitory effects were brought about by their ability to attach to the enzyme's active site. A novel imidazole derivative, (Substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanones was synthesized by diazotization reaction of substituted aniline forming intermediate 2-(Substitutes phenyl)-1-H imidazole and screened it for anti- HIV activity. New Chemical Entities anti-HIV-1 RT was investigated. It supports the possibility that these substances have HIV-1 RT inhibition activity.

Keywords: Imidazole, Docking, SAR, Diazotization, HIV-1RT.


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