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Abstract

FORMULATION AND EVALUATION OF TICAGRELOR ORODISPERSIBLE TABLETS

Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif and Maged Alwan Noman

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Abstract

Orodispersible drug-delivery system server major benefit over the conventional dosage forms because the drug disintegrate rapidly and dissolve in saliva without the use of water. Ticagrelor is one of the most recent antiplatelet agents used to inhibit platelet aggregation via blocking the Adenosine diphosphate (ADP) receptors of the subtype P2Y12, it used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death. Ticagrelor is used to prevent a serious or life-threatening heart attack or stroke, or death in people who have had a heart attack or who have acute coronary syndrome (ACS; blockage of blood flow to the heart). The present study is directed towards the development of formulation and evaluation of Ticagrelor Orodispersible tablets to improve the bioavailability of ticagrelor which shows 36% as ticagrelor is classified as a biopharmaceutics classification system (BCS) class IV drug with highly lipophilic having poor aqueous solubility and permeability increasing the solubility, improve the bioavailability and onset of action Ticagrelor has been done. The ODTs of various batches were prepared by using various concentrations of various superdisintegrants like sodium starch glycolate, crospovidone and croscarmellose sodium by direct compression and wet granulation method. In the initial preparation of formulation, we initially used the direct compression method for preparing F1 and F2, but its flowability was found to be weak. Therefore, we adopted the wet granulation method. In this study eleven formulations were prepared using certain selective excipients. All the prepared ODT formulations were evaluated for physical characteristics, disintegration, in-vitro dissolution, The hardness and the friability. The in-vitro dispersion time of all the formulation was done and in-vitro dissolution study of all the formulations was carried out for 5, 15 and 30 minutes according to the results formulation F11 was found as the best formulation which showed 101.45% drug release at 5 minutes and minimum disintegration time of 18 sec. It was concluded that F11 is the best formulation of Ticagrelor Orodispersible tablets in order to enhance the bioavailability of drug.

Keywords: Ticagrelor, Drug delivery system, Orodispersible tablets, Superdisintegrants.


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