Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF TRIBULUS TERRESTRIS EXTRACT CAPSULES DELIVERY SYSTEM AS AN ADVANCED PHYTOTHERAPY APPROACH FOR CONTROLLING DIABETES

Prof. Dr. Mahmoud Mahyoob Alburyhi* and Prof. Dr. Amina El-Shaibany

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Abstract

Diabetes is a serious health concern in many countries with high blood glucose, obesity, and multiple organ failures in late stages. Treating diabetes with effective drugs is still a challenging issue since most of the available diabetic drugs are not effective in combating diabetes, especially in secondary disease complications like obesity retinopathy, and nephropathy associated diabetes. Hence search for effective antidiabetic medication, especially from natural sources is mandatory with no adverse side effects. The Tribulus Terrestris is medicinal herb widely distributed in Yemen. It is medicinal herbs have been used in the treatment of diabetes, kidney disease, diuretic, antibacterial, liver disease, heart disease, anti-inflammatory, anti-tumor, anti-oxidant, anti-infertility, aphrodisiac activity, anti-stress, hepatoprotective activity, analgesic, antispasmodic and anthelmintic. In the present study the Tribulus Terrestris was formulated as capsules and evaluated for organoleptic properties of methanol extract of Tribulus Terrestris using tests as weight variation, drug content, in-vitro dissolution and other parameters. It was concluded that among the all formulations of Tribulus Terrestris extract capsules the F5 was found to be as an optimized capsules according to drug release percentage 94% within 60minutes in buffer medium, so the F5 was the best formulation of Tribulus Terrestris medicinal herbs extract capsules delivery system as an advanced phytotherapy approach for controlling diabetes.

Keywords: Tribulus Terrestris, Extract, Capsules, Medicinal herbs, Antidiabetic, Phytotherapy.