Abstract

SOLID DISPERSION: A REVIEW

Zaynab Nasikkar*, Sumit Tiwari, Radhika Vishwakarma, Pooja Tarmale, Nisha Verma and Mallika Turerao

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Abstract

Solid dispersion has sparked significant interest as an effective method to boost the dissolution rate and consequently the bioavailability of poorly water-soluble drugs. By employing water-soluble carriers, solid dispersions have effectively tackled issues linked to low solubility and improved dissolution. This technology underscores the importance of drug-polymer two-component systems, where the dispersion and stabilization of the drug are pivotal in formulation development. Despite the growing comprehension in recent years, commercial application remains limited. Various methods for preparing solid dispersions have been explored, with an emphasis on solubility, BCS classification, and carriers. The analysis also explores different types of solid dispersions based on the carrier employed and molecular arrangement, along with explanations of mechanisms and preparation techniques. Furthermore, it highlights recent technological advancements and offers insights into marketed drugs utilizing solid dispersion approaches.

Keywords: Solid dispersion, Drug solubility, Dissolution enhancement, Bioavailability, Polymer carriers, Hot-melt extrusion, Spray drying, Solvent evaporation.