Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLET OF ATORVASTATIN CALCIUM

Darshika Goswami*, Aakash Panwar, Vanshika Rathore, Aman Karma, Navdeep Jaiswal and B. N. Birla

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Abstract

Most of the orally administered dosage forms have several physiological limitations, such as GI transit time, impaired drug absorption due to incomplete release of drug from the dosage forms and too short residence time of the dosage forms in the absorption region of GI tract. Gastro Retentive Drug Delivery Systems (GRDDS) offer a promising approach to address these challenges, particularly for drugs like Atorvastatin calcium, which undergo rapid clearance in the intestine. Atorvastatin Calcium is a HMG-CoA reductase inhibitor used in treatment of hyperlipidemia. It undergoes high first pass metabolism. It is absorbed more in the upper part of the GIT. In This investigation describes the preparation and evaluation of gastro retentive floating tablets of atorvastatin calcium. One hydrophilic cellulose derivative, Methocel K4M were used in floating tablets as gel forming agents to control drug release. Sodium bicarbonate was incorporated as gas generating agents. The tablets prepared by direct compression technique were evaluated by various quality parameters including physical parameters, weight variation, hardness and Content uniformity.

Keywords: Gastro Retentive Drug Delivery, Atorvastatin calcium, Floating Tablet, HMG-CoA reductase.