Abstract

EFFECTS OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA AGONIST AND CINNAMON OIL ON OBESITY INDUCED BY HIGH-FRUCTOSE DIET

A. El Hasnaoui*, A. Mesfioui, I. Berkiks, M. Chakit, A. Kribii, A. Ouichou, A. El Hessni

Abstract

In this research, we investigated the effect of cinnamon oil and peroxisome proliferator-activated receptor alpha (PPARα) agonist (fenofibrate) on increase of obesity in rats induced by high-fructose diet (HFD). Animals received 23% (w/v) of fructose in water per day for 12 weeks. To determine the role of cinnamon oil on obesity, male wistar rats were randomized into four groups (6 rats per group): (i) control (standard diet), (ii) high fructose diet (HFD), (iii) HFD with fenofibrate at dose 100 mg/kg for 30 days and (iv) HFD with cinnamon oil at dose of 50 mg/kg for 30 days. The outcomes measured were body weight, body fat, fasting blood glucose, total cholesterol, highdensity lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglycerides, oral glucose tolerance test and weight organs. The values of glucose in blood, glucose intolerance, plasma total cholesterol, triglycerides, cholesterol (LDL) were significantly increased after 12 weeks of high fructose feeding; however, cinnamon oil and fenofibrate diet restricted the elevation of these parameters in comparison with the HFD fed to control group. In contrast, cholesterol (HDL) was slightly decreased in the HFD group and was increased in the groups treated by cinnamon oil and PPARα agonist. These results suggest that cinnamon oil had a regulative role of glucose intolerance, hyperglycemia, hypertriglyceridemia and hypercholesterolemia in high fructose-induced obesity rats, indicating a lower risk of obesity and its complications.

Keywords: Obesity, fructose, cinnamon oil, and peroxisome proliferator activated receptor, wistar rat.