Abstract

TOXICOLOGICAL EVALUATION OF MILK BASED RICE FLOUR BABY FOOD AS INCOMPATIBLE DIET [SAMYOGA VIRUDDHA]- AN IN VIVO STUDY

Dr. Rupesh M. Jadhav*, Dr. Savita C. Samleti and Dr. S. M. Lahankar

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Abstract

Introduction: Viruddha ahara (incompatible food) is one of the novel concepts given by the science of Ayurveda. It includes the incompatible food which hampers the normalcy of the Doshas and remains harmful to the bodily tissues.Fortified rice flour is the most common first solid food given to infants. It is with milk solid or have to be reconstituted with cow milk. Objective: To determine sub- acute toxicity of consumption of milk–based rice flour baby food in wistar rats with special reference to Samyoga Viruddha. Material and Methods: A sub-acute study was conducted on wistar rats following repeated dose. 28 days oral toxicity study was done according to 407 OECD guidelines. Various haematological, biochemical parameters along with histopathological examination were carried out to determine toxicological implication. Results: Repeated administration of milk based rice flour baby food and rice flour with milk did not show statistically significant changes in haematological, biochemical parameters. Histopathological examination of liver in both the group showed granular degenerative changes of mild to moderate severity. Conclusion: Changes in th liver histopathology indicates sub-acute toxicity with milk-based baby rice flour baby food. It shoes that Grain flour should not be mixed with milk. It is Samyoga viruddha or incompatible diet.

Keywords: milk base rice flour baby food, incompatible diet, Samyoga viruddha.