Abstract

GASTRORETENTIVE DRUG DELIVERY SYSTEM

Shruti Maruti Devkar*

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Abstract

The Pharmaceutical industry has lately shown growing interest in oral controlled release drug delivery to achieve greater therapeutic benefits, including patient compliance, simplicity of dosing administration and formulation versatility. GRDDS is a system that releases the active moiety in the stomach after being retained there for a significant amount of time. Eventually they are metabolised in the body in a controlled way. It is one of the medication delivery methods that is site specific for the stomach. This review was written with the intention of conducting research, gathering relevant literature, and succinctly presenting it. The current review briefly discusses the approaches, challenges, advantages, disadvantages and limitations as well as the bioequivalence and bioavailability study, as well as the factors influencing GRDDS and applications of Gastroretentive drug delivery system. High density (sinking systems), low density (floating systems), mucoadhesive, expandable, unfoldable, superporous hydrogel systems, raft forming system, magnetic systems are some of the different GRDDS approaches.

Keywords: Gastroretentive, anatomy, physiology, effervescent, microporous, swellable, raft forming, bioequivalence.