Abstract

ANTI-ULCER ACTIVITY OF MORINGA OLEIFERA LEAVE’S EXTRACT IN SWISS ALBINO MICE AGAINST ASPIRIN INDUCED PEPTIC ULCER

Hamid A. K.*, Shariq B., Jiyauddin K., M. Kaleemullah, Samer A. D.
Sakina R., Rasha S.

Abstract

The objective of this study was to evaluate the anti ulcer activity of Moringa Oleifera leaves in swiss albino mice against aspirin induced peptic ulcer. After administration of aqueous extract of Moringa Oleifera, ulcer index, protective index, evaluation and staining of EC cell and determination of mucosal thickness was evaluated. In biochemical parameters, free mucin content, lipid per oxidation, superoxide dismutase was evaluated. HE staining was performed as well. Ranitidine was used as a positive control. All the macroscopic and biochemical parameters showed significant anti ulcer activity of Moringa Oleifera. The anti ulcer activity was almost comparable to the positive control. P value less than 0.05 was considered significant. Mean ± S.E.M and one-way ANOVA followed by multiple comparison t-test were used to analyze the result. Our study shows that Moringa has considerable anti ulcer activity.

Keywords: Moringa Oleifera, Swiss albino mice, Aspirin, Peptic ulcer and Ranitidine etc.