Abstract

A REVIEW ON: SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM

Divya Kelan* and Nilesh Khutle

Abstract

Self-microemulsifying drug delivery systems (SMEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro- or nanoemulsions containing the solubilized drug. Owing to its miniscule globule size, the micro/nano-emulsified drug can easily be absorbed through lymphatic pathways, bypassing the hepatic first-pass effect. Solid-SMEDDS represent more effective alternatives to conventional liquid SMEDDS. Purpose of this study is to understand the fact of Solid-SMEDDS(S-SMEDDS) which provide characteristics of both SMEDDS as well as solid dosage form (e.g. excipients selection, specificity, characterization). S-SMEDDS is formulated by incorporating liquid/semisolid Self emulsifying ingredients into powders/ nano-particles form by different solidification techniques.

Keywords: Solid SMEDDS, hepatic first-pass effect, lymphatic pathway, liquid SMEDDS.