Abstract

STUDY OF ANALGESIC ACTIVITY OF MUCUNA PRURIENS EXTRACT ON SWISS ALBINO MICE

Sarvesh Singh, Anjula Sachan, Hemant Singh, Pratap Shankar*, Dheeraj Kumar, Amod Kumar Sachan, Rajendra Nath and Rakesh Kumar Dixit

Abstract

Mucuna pruriens, belonging to the family Fabaceae, has been used in traditional Ayurvedic Indian Medicine for various ailments. In the present study, we investigated the analgesic activity of the Mucuna pruriens extract was evaluated for its in-vivo analgesic activity by using the Eddy’s Hot plate method in mice. Three doses of Mucuna pruriens (100, 200, 400 mg/kg, p.o.) and standard dose of tramadol (25 mg/kg, i.p.) were used for treatment. Swiss albino mice weighing between 20-30 g using oral feeding tube were evaluated for analgesic activity at different time interval such as 0, 30, 60, 90, 120 and 150 minutes against standard and control group. Results indicate that the extracts could possess analgesic activity.

Keywords: Mucuna pruriens, Analgesic, Tramadol, Swiss albino mice.