Abstract

SAFETY OF INSULIN ADD ON THERAPY AND ORAL HYPOGLYCEMIC AGENTS (OHGAs) POLYPHARMACY IN TYPE - II DIABETES PATIENTS - A PROSPECTIVE OBSERVATIONAL STUDY

S. Sravanthi, P. Ramya*, K. Nani Babu, G. Anusha, Sk. Shafiya Begum

Abstract

Objectives: A clinical observational study conducted to compare the safety of Insulin add-on therapy and Oral Hypoglycemic Agents (OHGAs) polypharmacy and to promote safe use of insulin and OHGAs in Type II Diabetes patients, through patient counseling by Clinical pharmacist at Government General Hospital, Guntur. Methods: A Prospective Observational study was conducted on Type II Diabetes mellitus patients in General Medicine department in a tertiary care hospital, during the period of March to August of 2014. The work was carried out by using patient data collection forms and Diabetes questionnaire. Results: Among 193 study population with Type II Diabetes, OHGAs polypharmacy 46.25% (n=108) was found to be more than Insulin alone and Insulin add on therapy. Conclusion: From the study it was found that patients who are on OHGAs polypharmacy were subjected to GI disturbances and who are on Insulin therapy were subjected to hypoglycemic episodes. Considering the key role of pharmacist the safety of antidiabetic medications and adherence was improved through patient counseling.

Keywords: Insulin, safety, OHGAs, type II DM.