Abstract

A PROSPECTIVE STUDY TO ASSESS DRUG UTILISATION OF PROTON PUMP INHIBITORS AMONG PATIENTS IN A TERTIARY CARE HOSPITAL

Satish S.*, Sayanth S.* and Ramakrishna Shabaraya A.

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Abstract

Proton-pump inhibitors (PPIs) cause a profound and prolonged reduction of stomach acid production used to treat different acid related gastrointestinal disorders. However, concerns about PPI interaction, overprescribing of PPIs and side effects, have increased in recent years. The objectives of this study were to assess the PPI utilization by implementing Drug utilization Research. Drug utilization research is a multidisciplinary activity that is increasingly recognized as an important part of quality assurance wherever medications are used. Monitoring factors like DDD (Define daily dose), DDC (Define daily cost) and DUI (Drug utilization index) has been used. Ethical clearance was obtained, and data were collected regarding the PPI utilization over a period of 6 months at tertiary care hospital. Individual aged≥18 years with at least one dispensing PPIs were identified as PPI users and included in the study. Data were collected using data forms from patient medical records and analyzed using Microsoft Excel, Student T Test. The results revealed a PPI prescribing trend, allowing us to conduct drug utilization study. A DUI result of less than one indicates that the drug was administered appropriately. Apart from Rabeprazole (0.53) all PPI’s DUI values were more than 1, indicating that Rabeprazole was only given reasonably among research participants. The DDD value was determined to be highest in Pantoprazole and lowest in Lansoprazole. According to pharmacoeconomic analysis, DDC value was high for Omeprazole and low for Pantoprazole, resulting in increased use of it among the study population. To conclude with keeping in consideration the aim and objective, this study provided an insight into drug utilization research of Proton pump inhibitors in a tertiary care hospital. The data pattern of drug utilization was largely comparable to other studies conducted. It has been found the Proton pump inhibitors which is commonly used in heath sector has been prescribed irrationally which leads to increase in risk of adverse effects. Efforts should be made to limit PPI treatments to appropriate indications and ensure the choice of suitable PPIs promoting rational use.

Keywords: PPI, DUI, DDD, DDC, Rational.