Abstract

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEWER BENZIMIDAZOLE DERIVATIVES

Vikash Kumar Chaudhri*, Satyendra Singh and Devender Pathak

Abstract

Objective: Benzimidazoles are an important group of heterocyclic compounds which are biologically active. The main objective to synthesized a new series of N-1 as well as 2-substituted benzimidazoles N-{(2-Methyl/Mercapto-1H-benzo[d]imidazol-1-yl) methyl} substituted benzenamine (1a-1c) & (3a-3c), N-{(2- Methyl/Mercapto-1H-benzo[d]imidazol-1-yl)(substituted phenyl) methyl} substituted benzenamine (2a-2d) & (4a-4d) were synthesized. Methods: All the newly synthesized compounds have been characterized on the basis of analytical and spectral data. The compounds were evaluated for in-vitro antibacterial and antifungal activity using disc diffusion methods on nutrient agar medium. Results: All the synthesized compounds were confirmed by physical parameters (Solubility, melting point), chromatographic methods (TLC) and spectroscopic methods (IR, 1H NMR, Mass spectroscopy and elemental analysis). The newly synthesized compounds were screened for antibacterial and antifungal activity by disc diffusion methods on nutrient agar medium. The results revealed that newly synthesized compounds 2a, 2c, 4a and 4c were found to be potent against E. coli; 1a, 2b, 3a and 4b against B. subtilis; 1b and 3b against P. aeruginosa; 1c, 2d, 3c and 4d against S. aureus and antifungal activity 2b, 2d, 4b and 4d against C. albicans while 1a, 1c, 3a and 3c were found to be potent against A. niger. Conclusion: Modifications on benzimidazole moiety displayed valuable biological activities. Substituted benzimidazole exhibited significant to moderate antibacterial and antifungal activities.

Keywords: Benzimidazole, Antibacterial activity, Antifungal activity, Disc diffusion method.