Abstract

FROM MOLECULES TO MEDICINES: ADVANCE IN DRUG DESIGN AND DISCOVERY AND AN OVERVIEW ON KEY PROCESSES IN DEVELOPING SAFE AND EFFECTIVE DRUGS

Dr. Shoheb Shaikh, Pratiksha Anil Salunkhe, Harshada Sandeep Jadhav and Sunil Maniraj Yadav*

.

Abstract

The aim of present work is to study different stages of drug discovery and its significance to understand the different parameters, stages in drug development also to develop safe and effective drugs for unmet medical needs. The process of finding new drugs is still difficult and expensive, and it usually takes more than ten years from target identification to regulatory approval. Recent developments in experimental and computational techniques have improved efficiency and success rates by streamlining several phases of the drug discovery process. Target identification and lead optimization have been transformed by computational methods like molecular docking, virtual screening, and artificial intelligence, which enable more accurate predictions of drug-target interactions. By confirming biological activity and enhancing pharmacokinetics, experimental approaches like next-generation sequencing and high-throughput screening (HTS) enhance these computational approaches. The integration of computational and experimental methods in drug development is reviewed in this article, with a focus on how they might work together to save costs, increase accuracy, and shorten turnaround times. Successful application case studies highlight the advantages and difficulties of this multidisciplinary approach.[1]

Keywords: Drug discovery, Lead optimization, High throughput Screening (HTS), Virtual Screening, Pharmacokinetics, Computational techniques, Molecular docking, Drugtarget interactions.