Abstract

MICROWAVE - AN EFFECTIVE TOOL IN ORGANIC SYNTHESIS

Meenal Bhatre* and Shraddha Phadke

Abstract

Microwave-assisted organic synthesis (MAOS) is known for the spectacular accelerations produced in many reactions as a consequence of the heating rate, a phenomenon that cannot be easily reproduced by classical heating methods. As a result, higher yields, milder reaction conditions, and shorter reaction times can often be attained. Its specific heating method attracts extensive interest because of rapid volumetric heating, suppressed side reactions, energy saving, direct heating, decreased environmental pollutions, and safe operations. Microwaveassisted heating under controlled conditions has large impact on the fields of screening, combinatorial chemistry, medicinal chemistry and drug development because it often dramatically reduces reaction times, typically from days or hours to minutes or even seconds. Therefore, many academic and industrial research groups are already using MAOS as a forefront technology for rapid optimization of reactions, for the efficient synthesis of new chemical entities, and for discovering and probing new chemical reactivity .Microwave-assisted organic synthesis is now explored for scale-up with the help of continuous flow system. Another parallel technology involves a stop-flow process. These two types of systems would allow the pharmaceutical laboratory to produce large quantities of final products in a safe and efficient manner. This presentation focuses on the principle of microwave activation, various types of microwave reactor and its characteristics, processing techniques, advances in MAOS, application of microwave, advantages and disadvantages, precautions and safety.

Keywords: microwave assisted organic synthesis, time saving, efficient synthesis.