Abstract

AN INNOVATIVE REVIEW ON TARGETED DRUG DELIVERY SYSTEM BY USING FORMULATION SOFTWARE

Ch. Bhavani*, Balemla Sada, Kunal Bohara, Syed Yaseen Pasha, Yerram Shravya, Tadikonda Rama Rao

Abstract

A targeted drug delivery system enhances therapeutic concentration by selectively delivering drugs to specific areas, minimizing side effects and protecting healthy tissues. It utilizes various carriers to maintain the drug's integrity while targeting diseased organs. Over the past 60 years, drug delivery technologies have evolved through three generations, with the first focusing on controlled release and the recent generation addressing biological barriers. Key principles for successful drug targeting include effective drug loading, avoidance of degradation, precise delivery, and timed release. The application of targeted systems is essential for medications with instability, poor absorption, short half-lives, and low specificity. Advantages over traditional methods include reduced dosage frequency, improved bioavailability, and increased treatment efficacy. Different drug delivery approaches are employed for the central nervous system, including both invasive and non-invasive methods. Quantum dots and transdermal patches are examples of innovative delivery mechanisms.Targeted drug delivery shows promise in treating various diseases, including diabetes and cancer, and utilizes methods like liposomes and nanoparticles for high stability and specific targeting. Future research aims to further refine these systems to improve drug efficacy and reduce side effects.The application of Design of Experiment (DOE) methods aids in optimizing drug formulations, with a focus on enhancing the effectiveness of targeted therapies. A study on olanzapine showcased the potential of polymeric nanoparticles to reduce adverse effects while maintaining therapeutic action, revealing a trend towards more effective antipsychotic treatments with improved patient compliance.

Keywords: Targeted drug delivery system, Dose Dumping, Factorial design, Olanzapine, DoE.