Abstract

SINGLE ARM CLINICAL TRIAL TO ASSESS THE EFFICACY AND SAFETY OF SAPTARANGI BHAVIT VACHADI GANA IN DIABETES MELLITUS TYPE 2 ASSOCIATED WITH METABOLIC SYNDROME

*Dr. Amritpal Singh, Dr. Anil Sharma Dr. Neha Lamba

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Abstract

Madhumeha involves ten dushyas– 1. Abadh medha dhatu, 2. Mamsa 3. Kleda(jala), 4. Shukra 5. Shonita 6. Vasa 7. Majja 8. Lasika 9. Rasa 10. Oja. Acharya Charak described that Kapha in liquid state is main (Vishesha) dushya of Madhumeha. Vachadi gana mentioned in Ashtang Hridya Sutra Sthan have properties of Kapha Medhohar. Saptarangi is also well known drug for its antidiabetic property. It is mentioned in Nishakattakadi Kashaya by the name of Eknayakam in Sahastrayogam. As mentioned above that Vachadi gana has properties of kapha medhohar, which are main dushyas of Prameha and Saptrangi is drug of choice for diabetes. Therefore, it has been decided to consider Vachadi ghana with Saptarangi kwath Bhawana in Diabetes mellitus type 2/ Madhumeha associated with metabolic syndrome. First of all cytotoxicity of the drug was studied by performing MTT assay. Which was found non toxic. So it can be used for further clinical trials. Saptarangi bhavit vachadi gana was found to have a notable impact on all symptoms associated with Madhumeha. Most of the ingredients in the formulation are characterized by tikta, katu, kashaya taste and ushna potency. These properties contribute to its effects, including agni deepana, aampachana, medovishoshana, lekhana, srotosodhana, mutra (urinary detoxification) and vata anulomana. Statistical analysis indicates that the overall effectiveness of the therapy is approximately 30.7%.

Keywords: Diabetes mellitus, MTT assay, vachadi gana, Prameha, saptarangi, metabolic syndrome.