Abstract

THE REVIEW OF RECENT ADVANCE: “CHEMICAL BEHAVIOUR OF PYRIDOPYRIMIDINE DERIVATIVES AS ANTICANCER AGENT

Prof. Arati Bhetariya*, Dr. Dinesh K. Dangar, Ms. Morvi M. Raval, Ms. Payal H. Chhelana, Ms. Hetvi M. Sojitra, Ms. Krupali B. Jadav

Abstract

Cancer remains a leading cause of mortality worldwide, necessitating the development of novel and effective therapeutic agents. Pyridopyrimidine derivatives have emerged as promising anticancer candidates, exhibiting potent inhibitory activities against various cancer cell lines. This review aims to provide a comprehensive overview of the synthesized compound, their biological evaluation, and clinical potential of pyridopyrimidine derivatives as anticancer agents. We discuss the structural modifications, structure-activity relationships, and mechanistic insights underlying their anticancer properties from previous research. The review also highlights the current status of pyridopyrimidine derivatives in preclinical and clinical trials, as well as their potential combination therapies. Furthermore, we address the challenges and future directions in the development of pyridopyrimidine-based anticancer agents.

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