Abstract

A REVIEW ON HPLC METHOD FOR ESTIMATION OF AZELNIDIPINE

Krishnaphanisri Ponnekanti*, Addanki Anusha, Malavika Reddy and Omkar H.

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Abstract

Hypertension, also known as high blood pressure, occurs when the force of blood against the artery walls is too high. Azelnidipine (AZEL) is a dihydropyridine (DHP) type of calcium channel blocker (CCB) used for the treatment of hypertension. AZEL has two enantiomers due to an asymmetric carbon at 4th position of the DHP ring. The pharmacological action of AZEL resides in (R) - enantiomer and biological activity resides in (S) – enantiomer. High-Performance Liquid Chromatography (HPLC) is a type of column chromatography that is commonly used in biochemistry and analysis to separate, identify, and quantify active chemicals. A new simple, accurate and precise HPLC method has been developed and validated for estimation of Azelnidipine in its formulation. It is one of the most accurate methods widely used for the quantitative as well as qualitative analysis of drug product and is used for determining drug product stability.

Keywords: Azelnidipine, HPLC, Hypertension.