Abstract

EVALUATION OF IN-VITRO ANTI-INFLAMMATORY ACTIVITY FROM CORAL JUNCEELLA DELICATA COLLECTED FROM MADH ISLAND, WEST COAST OF MUMBAI

Borate M. P. and Zodape G. V.*

Abstract

The Gorgonia Junceella delicata was collected during low tides. The crude extract was prepared by adding an equal volume of MeOH: DCM (1:1) for 24 hours in the water bath at 45° C. The sample was filtered through Whatman filter paper No. 1 and was subjected to concentrate in a rotary vacuum evaporator at 45° C. The extract obtained was used to investigate the anti-inflammatory properties of the coral Junceella delicata and its potential as an alternative to standard drugs. Membrane stabilization and in-vitro anti-inflammatory activity were assessed using Heat-induced hemolysis, inhibition of albumin denaturation and proteinase action assays. The crude extract of coral Junceella delicata showed strong inhibition of RBC hemolysis (up to 89.13%), inhibition of protein denaturation (up to 72.04%), and proteinase inhibition (up to 88.60%), comparable to the standard drug diclofenac sodium. The study suggests that the coral Junceella delicata has potential anti-inflammatory properties. These findings may contribute to the search for effective biomedical property.

Keywords: Anti-inflammatory, Coral, Inflammation, Junceella delicata.