Abstract

METABOLIC DYSFUNCTION: A COMPREHENSIVE REVIEW OF PATHOPHYSIOLOGY AND TREATMENT STRATEGIES

Rushikesh S. Wandhekar*, Santosh B. Dighe, Achal K. Labade and Kalyani A. Kavade

Abstract

Metabolic dysfunction is a class of diseases that impair normal biochemical function, resulting in significant health impacts. Etiology of such malfunction arises through complex interactions among genetic, environmental, and lifestyle factors. The key mechanisms in pathophysiology involved are insulin resistance, chronic inflammation, and oxidative stress leading to complications like cardiovascular disease and renal impairment. This shall require a holistic approach in the management, including lifestyle changes, pharmacological treatments, and public health measures for prevention. In order to empower the population towards a healthy diet and regular exercise, education of the population on healthy diets and regular exercises will be required. The knowledge of genetic susceptibility and the exploration of potential therapeutic agents should further be researched to devise more potent interventions. Public health interventions will be improving access to healthy food and increasing physical activity in communities and regular screening for the risk factors of metabolic syndrome. Support groups will provide emotional support to the individual dealing with such conditions. Co-operation between healthcare providers, researchers, and community organizations can create an environment that places a priority on metabolic health. Indeed, metabolic dysfunctions are approached with integrative strategies which lead to good health outcomes by individuals as well as reduce the marvelous economic load on healthcare systems in the world. Metabolic disorders' understanding is very vital toward developing meaningful preventive strategies as well as helping therapeutic intervention to public health.

Keywords: Metabolic dysfunction, Insulin Resistance, Chronic Inflammation, Adipose Tissue, Pharmacological Interventions, Lifestyle Modifications.