Abstract

SYZYGIUM CUMINI SEED-EXTRACT MEDIATED GREEN SYNTHESIS OF CU NPS ANTIMICROBIAL, ANTIFUNGAL, AND ANTIOXIDANT EVALUATION

N. Sathish Kumar and R. Madharasi*

Abstract

The use of plant materials for the synthesis of nanoparticles represents a green technology. In this study, copper nanoparticles were synthesized by biologically reducing a copper sulfate solution using aqueous Syzygium cumini leaf extract at a pH of 5.0. The formation of copper nanoparticles was indicated by a color change from yellow to brown. The UV-Visible spectrum of the copper nanoparticles exhibited a surface plasmon resonance (SPR) peak at 517 nm. Drug resistance is a significant global issue, making it crucial to find substances that can combat multidrug-resistant (MDR) infections. This review aims to investigate the role of S. cumini in countering MDR microorganisms associated with human disorders, diseases, or infections, specifically targeting two bacterial species (S. aureus and E. coli) and two fungal species (Aspergillus niger and Candida albicans). The maximum zone of inhibition observed was from S. aureus, measuring 18.75 ± 1.06 mm, compared to 10.75 ± 0.35 mm for the fungal species. In terms of antioxidant activity, the DPPH-SC-CuNPs showed an IC50 value of 65.40 μg/ml across various concentrations (500 μg/ml, 250 μg/ml, 100 μg/ml, 50 μg/ml, and 10 μg/ml). This study could provide direction for clinical researchers regarding the future therapeutic applications of S. cumini in the prevention and treatment of infectious diseases.

Keywords: Syzygium cumi, sliver nanopartiels synthesis, antibacterial, antifungal activity and DPPH-SC-CuNPS.