Abstract

DESIGN, SYNTHESIS, AND ANTIBACTERIAL ACTIVITY OF NOVEL AMIDE-COUPLED 6-HYDROXY-N-PHENYL-9H-CARBAZOLE-3- CARBOXAMIDE PROMOTED BY DCC

K. Satya Veni, B. Ishwarya Laxmi and N. Krishnarao*

Abstract

The study of antimicrobials activity having a unique mode of action is a minimum requirement to solve problems of multi-drug resistance challenges. Here in, we have designed and prepared amide-coupled 6- hydroxy-N-phenyl-9H-carbazole-3-carboxamide (6a-6f) by acid-amine coupling reaction of 6-hydroxy-9H-carbazole-3-carbonyl chloride with substituted aromatic amines in the presence of strong base and dehydrohalogenating such as DCC. The intermediate 6-hydroxy-9Hcarbazole- 3-carbonyl chloride can be obtained from p-amino benzoic acid with p-benzoquinone in acetonitrile in the presence of a copper acetate in a alkali metal base and clean RBF. The copper acetate and caesium carbonate added in RBF. The synthesized amide-coupled scaffolds were characterized through 1HNMR, 13CNMR, as well as mass spectroscopic techniques. These analogous were evaluated for their antimicrobial against standard drug.

Keywords: 9H-carbazole-3-carboxylic acid, 9H-carbazole-3-carbonyl chloride, Nphenyl- 9H-carbazole-3-carboxamide derivatives, Bioevluation.