Abstract

MUCOADHESIVE FILMS FOR MOUTH ULCER THERAPY: KEY INSIGHTS FROM RECENT RESEARCH AND ADVANCEMENTS

Srushti Zade*, Dr. Rahul H. Kasliwal, Dr. Yogesh Gholse, Dr. Dinesh Chaple, Rupesh Kumar, Nishita Nagpure

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Abstract

Mucoadhesive films represent a promising strategy for addressing oral mucosal conditions such as mouth ulcers. They facilitate a close interaction between a bioadhesive material and biological membranes, utilizing ionic interactions that take place during hydration. This localized retention at the site of absorption can enhance the penetration of delivered medications, ultimately improving their bioavailability. Numerous studies have concentrated on improving the rate of drug release and ensuring prolonged retention in the oral mucosa, thereby enhancing therapeutic results. This review consolidates the findings from various research articles published on mucoadhesive films used in the treatment of mouth ulcers, offering a comprehensive examination of their formulation techniques and characterization. Key studies are summarized, emphasizing, on the effects of polymerplasticizer type, concentration, along with other excipients on formulation characteristics, including swelling, drug release rates, and stability of the system. Mucoadhesive films have shown potential in treating mouth ulcers by enhancing the release of drugs at the targeted site. Additionally, the review offers a current database of literature focused on the mucoadhesive film for mouth ulcer treatment.

Keywords: Mucoadhesive film, mouth ulcer, Box behnken design, polymers, drug release.