Abstract

DEVELOPMENT AND EVALUATION OF MATRIX- TYPE TRANSDERMAL DRUG DELIVERY SYSTEM OF VORICONAZOLE TO IMPROVE PATIENT COMPLIANCE

*Cholla Sandhya Rani, Pemmanaboina Bhavya Ganga Naga Sri, Pemmanda Sri Sai Vamsi, Pilla Anusha, Poojitha Yadav Nodagala and Pothula Uday Kumar

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Abstract

Objective: The present research work is an attempt to develop and evaluate matrix-type transdermal therapeutic system of Voriconazole in order to improve patient compliance by sustaining its action and by avoiding its gastrointestinal side effects. Method: Transdermal patches of Voriconazole were developed with different ratios of hydrophilic (HPMC) and hydrophobic (EC) polymer combinations by solvent evaporation technique. The Fourier transform infrared (FTIR) spectroscopy was used to confirm compatibility and to rule out any possible interactions between drug and polymers. Seven transdermal patch formulations (F1, F2, F3, F4, F5, F6 and F7) consisting HPMC E 5 and EC in the ratios of 5:0, 0:5, 1:1, 4:1, 1:4, 3:2, 2:3 respectively were prepared. All formulations carried 4 % w/v of Tween 80 as penetration enhancer and 10 % w/v of PEG 400 as plasticizer in dichloromethane and methanol (1:1) solvent system. The prepared patches were evaluated for their physicochemical characteristics such as physical appearance, weight variation, thickness, folding endurance, percentage moisture absorption, percentage moisture loss, water vapour transmission, tensile strength and drug content and in vitro drug release studies. Data of in vitro release from patches were fit in to different equations and kinetic models to explain release kinetics. Key Findings: Combination of polymers HPMC and EC (2:3) showed better release for sufficiently long time and emerged to be ideal formulations for Voriconazoleq. Conclusion: The developed transdermal films prolonged release for 24 hrs and thus found useful to improve the patient compliance of Voriconazole.

Keywords: Formulations; HPMC; in vitro; Voriconazole; Solvent evaporation technique; Transdermal patch.