Abstract

IN VITRO ANTIPLASMODIAL ACTIVITY OF THE LEAVES AND ROOTS OF HURA CREPITANS L. (EUPHORBIACEAE)

Anastasie Manga, Armel Diatta, Eliane Adélaïde Manga, Oumar Sambou, Mbaye Diagne Mbaye, Abdoulaye Gassama*, Sandrine Cojean and Christian Cave

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Abstract

Hura crepitans L. (Euphorbiaceae) is a Senegalese traditional pharmacopoeia plant used for treating malaria and other parasitic diseases around the world. In this study we did the extraction, the phytochemical characterization of the leaves and roots of Hura crepitans as well as the evaluation of its antimalarial activity while checking the cytotoxicity of extracts. Phytochemical characterization has shown that no molecule of the alkaloid family is detected in the leaves and roots and therefore the latter contain tannins and flavonoids. As for antiplasmodial activity, ethanolic extract from the leaves of Hura crepitans L. (ELHC) displayed the best antiplasmodial activity with an IC50 = 8.15 ± 0.95 μg/mL. However, the ethanolic leaves extract (ELHC) presents a certain degree of cytotoxicity with a CC50 = 49.56 ± 3.87 μg/mL.

Keywords: Hura crepitans L., in vitro, antiplasmodial, P. falciparum, cytotoxicity.