Abstract

DEVELOPMENT OF GEMIFLOXACIN MESYLATE A NOVEL APPROACH pH DEPENDENT OCULAR INSITU GEL FOR THE MANAGEMENT OF CONJUNCTIVITIS

*K. M. Manjanna, G. Shiva Krishna, G. Govind Reddy and Mohd Azharuddin

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Abstract

Ocular conjunctivitis is a common eye disorder like inflammation; redness and itching that are treated by traditional eye drops instilled in the eye surface but exhibiting very poor ocular bioavailability due to rapid naso-lachrymal drainage and precorneal elimination. The objectives of the present research work were to develop Gemifloxacin mesylate ocular in-situ gel containing Carbapol-934 as gelling agent, Hydroxy propylmethylcellulose (HPMC-K4M) as viscosity enhancer and subjected to evaluate for appearance, gel strength, pH, viscosity, gelation time, drug content and Invitro diffusion studies. FTIR studies suggest that there is no interaction between drug and excipients used in the formulation. All the formulations (F1-F5) show an acceptable range of pH, gel strength, gelation time. pH of the formulation batches was obtained in the range from 5.9± 0.22 to 6.8 ± 0.55.The concentration of Carbapol-934 significantly increases the viscosity in the range of 116 ± 0.92 to 398 ± 0.12cp and exhibits higher levels of drug content, 98.25 to 101.82 %w/w. Invitro drug diffusion from the formulated gel (F1-F5) was observed in the range 78.22 to 58.56 %w/w at the end of 6hr, revealing that the level of Carbapol-934 was predominantly sustaining the drug release. Based on the investigated results, the pH induced in-situ ocular gel is a superior alternative technique for administration of medicament instilled on the eye surface that undergoes sol-gel transition, after that enhances the precorneal residence time and ocular bioavailability.

Keywords: Gemifloxacin mesylate, pH induced in situ gel, Ocular drug delivery, Conjunctivitis, Carbopol, Invitro drug diffusion.