Abstract

NOVEL DRUG DELIVERY SYSTEMS: ADVANCING THERAPEUTIC FRONTIERS AND URSODEOXYCHOLIC ACID: PHARMACOKINETICS, PHARMACOLOGICAL PROFILE, CLINICAL APPLICATIONS, AND ADVANCED DRUG DELIVERY APPROACHES

Vaibhav Sharma*, Rahul Ancheria and Dr. M. K. Gupta

Abstract

Novel Drug Delivery Systems (NDDS) represent a paradigm shift from conventional drug formulations, offering sophisticated approaches to control drug release, target specific sites within the body, and improve patient compliance. This abstract explores the diverse array of NDDS, encompassing nanoscale carriers like nanoparticles, liposomes, and dendrimers; macroscale systems such as hydrogels and implantable devices; and stimuli-responsive platforms that release drugs in response to physiological or external triggers. We delve into the principles underlying these systems, highlighting their advantages in terms of enhanced bioavailability, reduced off-target effects, prolonged therapeutic action, and personalized medicine. Furthermore, the abstract discusses recent advancements and emerging trends in NDDS, including the integration of biomaterials, nanotechnology, and smart technologies to overcome existing limitations and unlock new therapeutic frontiers for a wide range of diseases. The landscape of pharmaceutical science is continually evolving, with a significant focus on enhancing the efficacy and safety of therapeutic interventions. Control drug release to regulate the rate and duration of drug release, ensuring optimal drug levels in the body over time. Targeted delivery. To deliver drugs specifically to the site of action (e.g., a tumor, a specific organ), minimizing exposure of healthy tissues and reducing side effects. Enhance bioavailability. To improve the absorption and availability of the drug in the body. Improve patient compliance To simplify dosing regimens, making it easier for patients to adhere to their medication. Protect the drug To shield the drug from degradation or inactivation before it reaches its target. The challenges and future perspectives in the translation of these innovative systems from bench to bedside are also briefly addressed.

Keywords: Novel Drug Delivery Systems, Targeted Drug Delivery, Controlled Release, Nanoparticles, Stimuli-Responsive Systems, Therapeutic Efficacy, Personalized Medicine.