Abstract

ANTIHYPERGLYCAEMIC ACTIVITY OF ETHANOLIC EXTRACT OF GREWIA ASIATICA (L.) LEAVES IN ALLOXAN INDUCED DIABETIC MICE

*Jitendra Bhangale¹, Sanjeev Acharya², Tushar Deshmukh³

Abstract

Grewia asiatica L. (Tiliaceae) is widely used in traditional system of medicine to treat diabetes in India. The ethanolic extracts (100, 200 and 400 mg/kg) were taken to evaluate the antihyperglycemic activity against alloxan induced diabetic mice. Oral administration of extract for acute study at 4 h resulted in a significant reduction of serum glucose level but the effect waned at 24 h. Repeated administration of extract for 28 days caused significant reduction in serum glucose level and body weight. Extract at dose of 400 mg/kg significantly suppressed the rise in blood glucose after 30 min in the acute glucose tolerance test. These results indicated that G. asiatica enhanced the antihyperglycemic activity and the extracts should further be subjected to bioactivity guided drug discovery to isolate a lead compound responsible for this activity.

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