Abstract

MOLECULAR DOCKING AND INSILICO STUDY OF SULPHONAMIDE DERIVATIVE WITH DIFFERENT DIABETES TARGET

Patange Sakshi Mahesh*, Aute Sagar Kondaji and Megha T. Salve

Abstract

Diabetes mellitus is a global health challenge with increasing prevalence and serious complications, including heart disease and organ damage. Effective management, particularly for type 2 diabetes, requires multifaceted treatment approaches to control blood sugar levels. Molecular docking study Omarigliptin was conducted with a binding pocket of Dpp-4, PPAR-γ, α-amylase, glycogen phosphorylase, and β-glucosidase Enzymes to elucidate the binding interactions of newly synthesized targets. Among the recently reported anti-diabetic agents is Omarigliptin, which has several pharmacological targets. In this review paper, pharmacokinetic characteristics and bioactivity score were predicted using Molinspiration software. Protox3.0 and 1-click docking software were utilized for in silico docking investigations. Protox3.0 software were used to toxicity prediction of Omarigliptin was examined, This review's main goal is to examine omargliptin's pharmacokinetic characteristics, bioactivity score, toxicity, and docking interaction between the the targeted protein and the ligand utilizing a range of software applications. A range of synthetic and natural compounds have demonstrated excellent modulatory effects on all major targets, namely: alpha amylase, DPP- 4, glucogen phosphorylase, PPARγ, β-glucosidase.

Keywords: Omarigliptin, Molecular Docking, Toxicity, In-silico Study, Diabetes mellitus.