Abstract

ADVANCES IN NOSE TO BRAIN DRUG DELIVERY SYSTEM: OVERCOMING CHALLENGES IN CNS THERAPEUTICS

Mohit Vikas Pawar*, Rutik Kisan Jadhav, Harshada Anil Ingle, Priti Dilip Kedar,

Abstract

Administration of nasal medications in the brain has become a promising non-invasive alternative to traditional methods for treating central nervous system (Central nervous system). In this review, taking into account the possibilities of this approach, we will first define a variety of new drug delivery systems, including classification. Then discusses brain complexity, body brain disorders, and nasal physiology, providing the basis for understanding the mechanisms of drug transport. A detailed study of the nasal delivery system is presented by comparing its advantages and disadvantages with other introductory routes. The main focus will explore a variety of nasal dosage forms, moving towards nose-to-brain delivery, particularly designed to treat brain disorders. This review plunges into the mechanisms in which drugs reach the brain via nasal pathways, highlighting intracellular and extracellular pathways. Finally, he demonstrates the application of nasal volume in the treatment of many brain diseases and provides a comprehensive overview of the current state and future directions for the delivery of drugs through the nose.

Keywords: NDDS, Nasal, Brain, Brain Disorder, BBB, Olfaction.