Abstract

URINARY HYDROXY PROLINE IN PATIENTS OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS- A COMPARATIVE STUDY

Dr.P.Kiranmai MD and Dr.Ramashouri MD

Abstract

Introduction: Hydroxyproline is present almost entirely in collagen. Bone tissue pathologies are reflected in the metabolism of hydroxyproline as are articular connective tissue pathology .Hence the study was conducted to compare the levels of hydroxy proline in urine of patients of Rheumatoid arthritis and osteoarthritis to study if hydroxy proline urinary values can be used for differentiating the two conditions. Materials and Methods 25 normal healthy volunteers working in Gandhi Medical College participated in the study to form the control group. Study includes 50 cases of arthritis. Cases are divided into two groups. Group I includes 25 cases of established rheumatoid arthritis patients and Group II includes 25 cases of established osteo arthritis. Both control and study group persons were advised to have collagen free diet for two days. Hydroxy proline and creatinine are estimated in 24 hrs urine sample in control and study groups. Results: There is a statistically significant increase in hydroxy proline excretion in group I when compared to control group.(p0.05). Excretion of hydroxyproline in group I cases is more than in Group II cases (p

Keywords: Rheumatoid arthritis, Osteoarthritis, Urine Hydroxyproline.