Abstract

FORMULATION & EVALUATION OF LEVOFLOXACIN & RANITIDINE GASTRORETENTIVE FLOATING MATRIX TABLET

Hemant Kumar Dhaneria*, Sukhwant Singh and Jitendra Banweer

Abstract

The purpose of this research was to develop gastro-retentive delivery system of levofloxacin and ranitidine, which was prolonged drug delivery and GI tract, is to control the gastric residence time with desire in vitro release profile. The formulation of levofloxacine & ranitidine floating matrix tablet at the different parameters for the prevention of GERD and Emesis simultaneously. The tablets were prepared by direct compression method using variables concentration of HPMC and CMC with citric acid, Sodium Bi Carbonate, Talc and Magnesium Stearate. The tablets were evaluated for in vitro release for 12 hours. The tablets were prepared by the combination of HPMC E15 and CMC Shows better floating ability as well as better release profiling.

Keywords: Levofloxacin, Ranitidine, Gastro-retentive floating matrix tablet, GERD and Emesis.