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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

HEPATOPROTECTIVE ACTIVITY OF VITEX NEGUNDO LINN AGAINST CCL

S Arumanyagam, M Arunmani, J Sathakkathul Zariya and S Geetha*

Abstract

Vitex negundo are used traditionally as an anti–hepatoprotective herbal medicine. To study the hepatoprotective effect of V.negundo, we checked methanol leaves extract against carbon tetrachloride (CCL4). CCL4 is a well characterized hepatotoxin and inducer of CYP 2E1 which induced toxicity in HepG2 liver cells. In the present study, we showed the inhibitory effect of V.negundo against CCL4 toxicity, by decreasing the apoptotic gene expression in HepG2 cells and protect the liver cells against toxicity.

Keywords: Apoptosis, Vitex negundo, CYP 2E1, HepG2 cells.

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