Abstract

EFFECT OF TERMINALIA CHEBULA FRUIT EXTRACT ON HIGH FAT DIET AND ETHANOL INDUCED INFLAMMATION IN PANCREAS

Amutha Mariappan, Geetha Arumugam* and Amutha Marimuthu

Abstract

The effect of hydro alcoholic fruit extract of Terminalia chebula (HAETC) on ethanol (EtOH) and high fat diet (HFD) induced changes in pancreas was investigated in rats. Male albino Wistar rats of Group1 and 2 served as control and received normal diet (5% fat). Group 3 and 4 rats were administered orally with EtOH and also fed HFD (25% fat) for 90 days. In addition, groups 2 and 4 rats received 100 mg/Kg body wt of HAETC for the last 60 days. We observed a significant decrease in the activity of serum lipase, amylase, pancreas level of caspase-1 and myeloperoxidase in rats co-administered with HAETC than in EtOH and HFD control rats. The HAETC co-administered rats showed a significant decrease in total cholesterol, triglyceride and LDL levels and maintained the antioxidant status in HFD-EtOH fed rats. Histopathology of liver and pancreas added more evidence for the antiinflammatory property of T.chebula. The study revealed that T.chebula fruit extract significantly reduced the inflammation probably by modulating the activity of caspase-1 and maintaining the antioxidant status in pancreas.

Keywords: Antioxidants, ethanol, high fat diet, inflammation, pancreas, Terminalia chebula.