Abstract

ADVANCES IN THE DEVELOPMENT OF INNOVATIVE DOSAGE FORMS FOR FIXED-DOSE COMBINATIONS OF ACTIVE PHARMACEUTICAL INGREDIENTS

Subhiksha R.* and R. Kumaravelrajan

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Abstract

The review article delves into the recent advancement in Fixed-Dose Combination of Active Pharmaceutical Ingredients. An attempt is made to explore the strides made in enhancing drug stability, which is paramount for maintaining efficacy and extending shelf life. These fixed dose combinations and enhancing therapeutic success. FDCs are often employed in the management are aimed at streamlining treatment regimens, enhancing drug compliance, of chronic diseases such as diabetes, hypertension, and infective disorders, where the management of the condition using a combination of drugs is effective. Improved convenience, reduced pill burden, and potential cost savings are the primary benefits of FDCs. The development of fixed-dose combinations (FDCs) resulted from efforts to address the incompatibility of active ingredients. The use of several novel formulation technologies for FDC medications including multilayer tablets, bilayer systems, and 3D printing, is covered in this review. Conclusion: In conclusion, the developments in FDC provide creative answers to the ever-changing demands of contemporary medicine.

Keywords: Fixed dose combination (FDC), bilayer, multilayer tablets, gastric retention of oral dosage forms, 3D printing.