Abstract

FORMULATION AND EVALUATION OF HERBAL ANTIFUNGAL GEL OF HEMIDESMUS INDICUS AND TRIDAX PROCUMBENS

Sakshi Dipak Patade*, Sakshi M. Patil, Swarangi Ravindra Desai, Sakshi Sardar Shevale and Jeevak B. Naik

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Abstract

The two notable plants selection was done by studying their various activity. These plants were collected and shade dried for about 15 days. The authentication of two plants was done. Herbal plants extracted by using maceration and soxhalet apparatus respectively. Phytochemical screening was performed by ultraviolet and infrared spectroscopy, by these methods we confimed the presence of functional groups mainly rutin and quercetin which shows mainly antifungal activity. Through studying various antifungal topical dosage form we found that using these herbs (H.indicus and T. procumbens) no formulation was prepared. We choosed to prepared gel formulation because theirs fast absorbing property, lightweight and non greasy texture. The gel was formulated using respective herbal extract. After evalution of the gel and MIC of formulation against fungus Candida albicans we found that these two drugs show maximum activity at low concentration i.e they show potent activity (2.5% for 100μg). These drug are easily available. They are used for various diseases treatment (antidiabetis, anticarcinogenic, antiulcer, antiarithritis). These are less toxic and affordable.

Keywords: Hemidesmus indicus, Tridax procumbens, Antifungal activity, Candida albicans, Herbal Antifungal gel.