Abstract

PREVALENCE AND ANTI-BIOGRAM OF UROPATHOGENS IN A TERTIARY CARE HOSPITAL

Dr. Sunil Kumar Biradar¹, *Dr. Srikanth², Dr. Praveen Kumar Doddamani³

Abstract

Urinary tract infection (UTIs) is one of the most common bacterial infections seen in clinical practice particularly in developing countries. Despite the advances in the antimicrobial therapy, UTIs remains a major health hazard. This was a retrospective study conducted in a tertiary care hospital to know the prevalence and antibiogram of uropathogens. Out of 952 samples tested, 538 (56.5%) were positive cases. Gram negative organisms (GNO) accounted for 78.81% of the total cases, Gram positive organisms (GPO) accounted for 19.7% of the cases and remaining were candida. Among GNO, E.coli was highly resistant to Ampicillin (98.8%), Nalidixic acid (98.5%), Cefotaxime (68.8%) and least resistant to Imipenem (0%) and Nitrofurantoin (15.7%). Klebsiella spp when compared with E.coli showed less resistance to Ceftriaxone, Cefotaxime and Norfloxacin, but showed higher resistance than E.coli to Ampicillin/Sulbactum, Amikacin and Nitrofurantoin. Pseudomonas spp showed highest resistance to Ampicillin (97.5%) and least to Imipenem (0%). Among GPO, S.aureus showed high resistance to Ampicillin (86.1%) and least resistance (0%) to Vancomycin, Teicoplanin and Linezolid. Coagulase negative staphylococci showed high resistance to Amoxicillin/Clavulanic acid (84.6%) and least resistance (0%) to Vancomycin, Teicoplanin and Linezolid, but Enterococcuss spp showed resistance to Vancomycin (4.5%) and Teicoplanin (9.09%). Knowledge of uropathogens and their antimicrobial susceptibility pattern will help in selecting an appropriate antibiotic for empirical therapy of UTI. Formulation of hospital infection control committee and strict adherence to the guidelines of the committee will help in preventing the emergence of drug resistance.

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