Abstract

DEVELOPMENT AND CHARACTERISTICS OF DOXYCYCLINE OINTMENT FOR THE TREATMENT OF PLAGUE DISEASE

*Muskan Mandal, Shubham Kumar Deshmukh, Prince, Suman Verma, Anjali Sahu, Devorat Singh

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Abstract

Yersinia pestis is the human pathogen that causes pneumonic, septicemic, and bubonic plague. Its impact on past and present human populations is examined, along with its historical background, bacteriological traits, genomic study based on ancient DNA (aDNA), and contemporary strains. To learn more about the causes, spread, and impacts of plague on various communities, the findings of several studies have been combined. The molecular interactions of Y. pestis are also taken into consideration, including its evolutionary history, adaptation to flea-borne transmission, and effects on both human and wild populations. The distinctive aDNA pattern combinations that are essential to the reconstruction and examination of ancient genomes are reviewed. Bioinformatics is fundamental in identifying specific Y. pestis lineages, and automated pipelines are among the valuable tools in implementing such studies. Plague, which remains among human history’s most lethal infectious diseases, but also other zoonotic diseases, requires the continuous investigation of plague topics. This can be achieved by improving molecular and genetic screening of animal populations, identifying ecological and social determinants of outbreaks, increasing interdisciplinary collaborations among scientists and public healthcare providers, and continued research into the characterisation, diagnosis, and treatment of these diseases.

Keywords: Ancient DNA, Yersinia pestis, plague, and bioinformatics.