Abstract

WHEN DRUGS TURN DEADLY: UNDERSTANDING TORSADES DE POINTES

Dr. Madhanraj N.* and Mr. Jeba Ruban F.

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Abstract

This article explores drug-induced Torsades de Pointes (TdP), a severe cardiac arrhythmia. It details cases involving intravenous amiodarone, where 1.5% of patients developed TdP, recovering without mortality. Extreme eperisone overdose and polypharmacy in elderly patients significantly elevate TdP risk due to QT prolongation and drug interactions. Other causative agents include clarithromycin, ondansetron, levetiracetam, loperamide, and moxifloxacin, often exacerbated by electrolyte imbalances. Women exhibit higher susceptibility to drug-induced TdP. Additionally, cannabinoid use and antipsychotic polypharmacy are identified risks. The article underscores the critical need for vigilance in prescribing and monitoring to prevent this life-threatening condition.

Keywords: Torsades de Pointes (TdP), QT Prolongation, Drug- Induced Arrhythmias, Cardiac Toxicity.