Abstract

GASTRORETENTIVE DRUG DELIVERY SYSTEMS, A STRATEGIC APPROACH FOR ENHANCED GASTRIC RETENTION AND THERAPEUTIC EFFICACY

Puja Mishra* and Dr. N. Trilochana

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Abstract

Gastroretentive drug delivery systems (GRDDS) are innovative oral drug delivery technologies designed to prolong the gastric residence time of drugs, thereby improving bioavailability, especially for drugs that are preferentially absorbed in the stomach or upper gastrointestinal tract. This review highlights the physiological considerations, mechanisms of gastroretention, various types of GRDDS including floating, bioadhesive, expandable, and high-density systems, as well as recent advances in formulation strategies. Factors influencing gastric retention and current challenges are also discussed. The integration of GRDDS in therapy has shown significant clinical promise in optimizing therapeutic outcomes.

Keywords: Gastroretentive, drug delivery, floating system, mucoadhesion, gastric retention, controlled release.