Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE IN-SITU BUCCAL GEL OF CHOLINE SALICYLATE AND CURCUMIN

Danish Asad Baig*, Dr. Rehan Deshmukh and Dr. G. J. Khan

Abstract

Background: Periodontitis is a chronic inflammatory disease of the periodontium that often requires localized therapeutic intervention for effective management. The buccal delivery of drugs using in-situ gels provides a promising approach due to its ability to enhance drug residence time, improve patient compliance, and enable sustained drug release at the site of action. Objective: This study aimed to formulate and optimize mucoadhesive in-situ buccal gel containing Curcumin and Choline Salicylate for the localized treatment of periodontitis usi ng a systematic Box–Behnken Design (BBD) approach. Methods: Twelve batches (F1–F12) were developed using varying concentrations of Poloxamer 188 and Carbopol 934. The gels were evaluated for physical appearance, pH, gelation temperature and time, spreadability, viscosity, mucoadhesive strength, drug content, and in vitro drug release. Statistical optimization was performed targeting gelation temperature (~37 °C), viscosity (

Keywords: Periodontitis, Buccal Drug Delivery, In-Situ Gel, Curcumin, Choline Salicylate, Thermoreversible Gel, Mucoadhesion, Box–Behnken Design.