Abstract

DEVELOPMENT AND CHARACTERIZATION OF SINGLE LAYER OSMOTIC CONTROLLED RELEASE TABLET FOR LOW SOLUBLE DRUG NORFLOXACIN

Abhishek Yadav^*, Pranav Kumar Upadhyay and Rajiv Shukla

Abstract

The aim of the present research work were to develop and characterize single layer osmotic controlled release tablet for low soluble drug Norfloxacin by using direct compression, coating and drilling technique by using various different concentration of excipients. Now a days, the drug delivery system are becoming more difficult day by day, as pharmaceutical researchers dealing with new techniques for the better understanding of biochemical and physicochemical properties to make their performance better. As we know, the Novel Drug Delivery System is a great approach in the field of Pharmaceutical preparation, the Osmotic Drug Delivery System provides more easy ways for the patient compliance. There are various methods which are used for the preparation of different types of osmotic pump tablets, the drug which is taken here is Norfloxocin by applying direct compression methods associated with coating and drilling process. In this research work, we had prepared single layer osmotic pump tablet of norfloxocin to fulfil it’s low solubility profile and better patient compliance. There are total six types of formulations was prepared with different concentrations of excipients by using direct compression method, and coating of tablets and drilling of tablets were performed for better release of drugs due to osmosis process. The granules of tablets and prepared tablets were evaluated for different parameters. From all the result and readings, it can be concluded that, the single layer osmotic pump tablet is found to be better option for the drugs having poor solubility.

Keywords: Osmosis, Osmotic Drug Delivery System, NDDS, Elementary osmotic drug tablet, etc.