Abstract

THE GUT-BRAIN AXIS AND ISCHEMIC STROKE

Dhanadevan K. S.*, Jefrin J., Anish Paul R. and Shanmuganathan D. K.

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Abstract

The gut-brain axis initiates the complex interaction between the gut and the brain, and ischemic stroke is one of the primary causes of impairment. This review initially looks at the epidemiological burden, historical context, and intricate pathophysiology of ischemic stroke before delving into the relationship between the gut and brain axis. We provide an overview of the current understanding of how gut dysbiosis in stroke, characterized by alterations in the gut microbiota, exacerbates ischemia-reperfusion (IR) deficit. We examine the unique effects of gut microbiota organisms on inflammation and neuronal damage following a stroke. We also discuss promising approaches for the future, including the possibility for fecal microbiota transplantation (FMT), specific supplements, and fermented foods to reduce strokerelated neurological deficits. This study attempts to lay the groundwork for creating innovative gut-targeted therapies to enhance stroke outcomes by thoroughly examining the role of the gut-brain axis in ischemic stroke.

Keywords: Ischemic stroke, Gut-brain axis, Gut microbiome, Ischemia Reperfusion injury, Faecal microbiota transplantation.