Abstract

FORMULATION AND EVALUATION OF GATIFLOXACIN TOPICAL SEMISOLID DOSAGE FORMS

Mohamed A. El-Nabarawi*, Ahmed H. El-Shafai and Dina M. Mahmoud Abdelfattah

Abstract

The aim of this work is to formulate Gatifloxacin in different semisolidpreparations including gels and emulgels of good rheological andrelease properties. All formulations contained 0.1w/w%Gatifloxacin(GF) concentration. Results showed that all semisolidformulations depicted acceptable physical properties, all gel andemulgel formulations followed non Newtonian, pseudoplastic flow,Allformulations depicted thixotropic behavior with varying recoveryrate.Polymers and formulations of lower viscosities achieved rapidrecovery.Sodium carboxy methylcellulose(SCMC) gel(2w/w%)showedthe most rapid recovery compared to other gel and emulgelformulations, Polymer concentration highly affected the degree ofshear rate and shear stress. It was found that FEg7 depicted the highestdrug release and permeation compared to the other emulgel formulations .Therefore it is themost suitable formulation for topical formulation.

Keywords: Gatifloxacin, Gel, Emulgel, Polymers.