Abstract

SEROPREVALENCE OF CYTOMEGALOVIRUS ANTIBODIES AMONG HEMODIALYSIS PATIENTS IN GEZIRA STATE, CENTRAL SUDAN

Abu Algasim E. Abd Alla, Altayeb A. Altayeb, Mohammed A. Alshareef, Mohammed S. Elboni, Salah Eldin Ali, Khalid O. Abosalif, Waled A. Ahmed, Khalid E. Khalid, Haitham E Elawad* and Ehab I. El-Amin

Abstract

Objective: To investigate the seroprevalence of Cytomegalovirus (CMV) antibodies among hemodialysis (HD) patients in Gezira State, Central Sudan. Design and Methods: Across sectional study was conducted at Gezira Hospital for Renal Diseases and Surgery (GHRDS) in 93 hemodialysis patients. Indirect Enzyme-linked immunosorbent assay (ELISA) was used to investigate anti-CMV IgM and IgG. Structured questionnaire was used to gather sociodemographic data. Results: In hemodialysis patients, the positivity for anti-CMV IgM and anti-CMV IgG were found in 45.2% (42/93) and 95.7% (89/93) respectively. The number of hemodialysis patients subjected to blood transfusion and previous surgery were 79 (84.9%) and 42 (45.2%) respectively. The percentage of anti-CMV IgM and anti-CMV IgG were 45.6% and 97.5%; 47.6% and92.9% amonghemodialysis patients received blood transfusions and subjected to previous surgery respectively. Conclusions: The prevalence of CMV infection among hemodialysis patients in Gezira state appears high. Blood transfusion was found to play a major risk factor predisposing to CMV infection.

Keywords: Cytomegalovirus, Antibodies, Hemodialysis, Sudan.