Abstract

HORMONAL PROFILE AMELIORATION BY THE MIXTURE OF VITEX-AGNUS CASTUS AND METFORMIN ON POLYCYSTIC OVARY REMEDY

Shereen Said Elshaer, Hend Mohamed Anwar* and Mamdouh Salah El-Din Zohni

Abstract

Aim: This study was aimed to ameliorate the effect of Metformin (Met) in Polycystic Ovary (PCO) treatment. Materials and Method: Forty rats were classified into 4 groups (10 Rat each): Control group, Dehydroepiandrosterone (DHEA) group, DHEA+ Met group and DHEA + Met + Vitex Agnus-Castus (VAC) group. After 30 days of injection; Luteinizing Hormone (LH), Follicular Stimulating Hormone (FSH), Prolactin (PRL) and some biochemical parameters were assayed in serum. Results: The results showed an elevated FSH and PRL but depressed LH levels in DHEA group. But significant changes were demonstrated in DHEA + Met group. Obviously, very highly significant ameliorations were obtained in DHEA + Met + VAC group. Conclusion: This study confirms that the treatment by the mix of Met and VAC ameliorating the hormonal levels and providing a new therapeutic modality for PCO.

Keywords: Polycystic ovarian syndrome, Metformin, DHEA, and Vitex Agnus-Castus.