Abstract

FORMULATION AND EVALUATION OF SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEM OF PRAMLINTIDE

Anbarasu Murugan*, Kamal Karunanithi, Mishba A., Senthilkumar Krishnan, Kannabirran Vaikundam

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Abstract

Nanoemulsion-based drug delivery systems have gained significant attention for improving the oral bioavailability of peptide-based drugs. Pramlintide, a synthetic analogue of human amylin, is an antidiabetic agent used in the management of type I diabetes mellitus. Due to its peptide nature, pramlintide exhibits poor oral bioavailability and therefore requires parenteral administration, leading to reduced patient compliance. This study aimed to formulate and evaluate a selfmicroemulsifying drug delivery system (SMEDDS) of pramlintide to enhance its solubility, stability, and suitability for oral administration. A series of SMEDDS formulations with varying oil-to-surfactant ratios were prepared and evaluated for self-emulsification, robustness, zeta potential, viscosity, drug content, and in vitro dissolution. The optimized formulation demonstrated a mean zeta potential of –22.6 mV, drug content of 99.1 ± 0.37%, and >99% transmittance. In vitro drug release in pH 1.2 buffer showed more than 92% release within 45 minutes. These findings suggest that SMEDDS is a promising strategy to improve the oral delivery and patient compliance of pramlintide for the treatment of type I diabetes mellitus.

Keywords: Nanoemulsion, Pramlintide, Type I Diabetes, SMEDDS, Oral Bioavailability, Antidiabetic drugs.