Abstract

A REVIEW ARTICLE ON DESIGN AND EVALUATION OF COLON TARGETED MODIFIED PULSINCAP DELIVERY

Bhavna Singh*, Mahima Trivedi, Dr. Ritesh Jain

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Abstract

This study aimed to create, design, and test a special kind of medicine capsule that releases drugs directly in the colon. The main goal was to make the medicine stay in the stomach and small intestine for a while before releasing it slowly and exactly in the colon. This would help the medicine work better and cause fewer side effects in the rest of the body. To do this, the outer part of the hard gelatin capsule was changed so it would not dissolve quickly. This was done by exposing it to formaldehyde vapor. The capsules that weren’t treated stayed soluble. The medicine, which included metronidazole, was put into the treated capsules along with other ingredients that help control how fast the medicine is released. A special coating was added to stop the medicine from dissolving in the stomach and small intestine. The capsules were tested for several things like how they looked, their weight, how evenly the medicine was inside, how quickly they broke apart, how the medicine came out in a test setup, how long it took before the medicine started to come out, and how the medicine was released over time. The results showed that the modified capsules worked well, with a delay before releasing the medicine, and then releasing it in the colon as planned. The study suggests that this new type of capsule is a good way to deliver medicine directly to the colon, especially for drugs like metronidazole. It can improve how well the medicine works and make it easier for patients to take. Keywords: Pulsincap; Metronidazole; Colon targeted drug delivery system; Capsules.

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